An overview of the variability in SNCA, SNCB, and SNCG in the general population and the potential role of each gene in human disease


The SNCA locus currently has an indisputable role in Parkinson's disease and other synucleinopathies. The role of genetic variability in the other members of the synuclein family (SNCB and SNCG) in disease is far less clear.