There are clear acute- and delayed-phase patterns of neurological disease evident in children with SARS-CoV-2 infection, but more studies are needed.
Why this matters
Neurological complications of COVID-19 have been reported in numerous adult patients, including a high incidence of ischemic stroke and intracerebral hemorrhage.
In children, an inflammatory process during latency of SARS-CoV-2 has been reported, known as multisystem inflammatory syndrome in children (MIS-C) or pediatric inflammatory multisystem syndrome-temporally associated with SARS-CoV-2 (PIMS-TS).
It is understood that around 34% of children with MIS-C have neurological symptoms, but consolidated data on the central nervous system (CNS) manifestations of COVID-19 in children are lacking