Compared with aspirin alone, the addition of ticagrelor significantly reduced the 30-day risk of disabling stroke or death in patients who had a noncardioembolic acute ischemic stroke.
Why this matters
Disability 3 months after stroke onset has been reported to be an independent predictor of future death. Disability after a transient ischemic attack (TIA) or ischemic stroke may be caused by damage from the index stroke or a subsequent stroke.
Reducing subsequent disabling stroke is the main goal of preventative treatment in the acute setting after TIA or ischemic stroke.
Ticagrelor was able to prevent disabling stroke or death at 30 days and reduce the total burden of disability in patients with TIA or minor ischemic stroke, thus may be a useful therapy for improving long-term outcomes following TIA or ischemic stroke.