Treatment with methylprednisolone for individuals with neuromyelitis optica spectrum disorder


  • Treatment with high-dose intravenous methylprednisolone (IVMP) pulse therapy was necessary to preserve the long-term visual outcomes in individuals with neuromyelitis optic spectrum disorder (NMOSD) who were anti-aquaporin-4 immunoglobulin G (AQPR-IgG) positive.

Why this matters

    Individuals with NMOSD often present repeated attacks of optic neuritis (ON). During acute attacks of ON, the gold standard treatment is high-dose IVMP. For chronic attacks of ON, there is no standard strategy, however, low-dose corticosteroids are often used to prevent relapse. Without proper treatment, individuals with chronic attacks of ON eventually become wheelchair bound and/or blind.



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